• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Skip to secondary sidebar
  • Skip to footer

  • Opinion
  • Health IT
    • Behavioral Health
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Patient Engagement
    • Population Health Management
    • Revenue Cycle Management
    • Social Determinants of Health
  • Digital Health
    • AI
    • Blockchain
    • Precision Medicine
    • Telehealth
    • Wearables
  • Startups
  • M&A
  • Value-based Care
    • Accountable Care (ACOs)
    • Medicare Advantage
  • Life Sciences
  • Research

UM Spinout Fifth Eye Lands $11.5M for Early Warning Patient Deterioration System for Hospitals

by Fred Pennic 04/01/2019 Leave a Comment

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

UM Spinout Fifth Eye Lands $11.5M to Expand Clinical Early Warning Systems for Hospitals

Fifth Eye, a medical device software spinoff from the University of Michigan building clinical early warning patient deterioration system for hospitals has raised $11.5 million in Series A funding led by Arboretum Ventures and Cultivation Capital. Other participants in the round include were MINTS, the direct investing arm of the University of Michigan’s endowment, along with additional capital from previous investors Invest Michigan and 35 private angel investors.

Why Clinicians Need A Better Detection System for Unexpected Patient Deterioration

Clinicians need a better detection system for unexpected patient deterioration. Hemodynamic instability, which is when blood flow to vital organs degrades to levels that are insufficient to support vital organ functions, is one of the most common causes of deterioration and death for critically ill or injured patients, especially when it manifests unexpectedly or goes undetected. Common causes leading to hemodynamic instability include hemorrhage/post-operative bleeding, sepsis caused by serious infections like pneumonia, various acute brain injuries, respiratory difficulties, and others. Hemodynamic instability resulting from these conditions can lead to sudden low blood pressure, heart failure and cardiac arrest.

Fifth Eye Background

Founded in 2017 by serial entrepreneur Jen Baird, CEO and a team of three researchers from the Michigan Center for Integrative Research in Critical Care (MCIRCC), Fifth Eye’s mission is to improve the quality and cost of care with intuitive real-time early warning systems using continuous physiologic waveforms.

The Ann-Arbor, Michigan-based company is developing clinical early warning systems based on physiologic waveforms to improve outcomes and reduce costs using license technology from MCIRCC’s Advanced Analytics Platform and two predictive analytics, the Analytic for Hemodynamic Instability (AHI) and Barreleye. AHI uses sophisticated real-time signal processing to predict if a patient will deteriorate several hours before normal vital signs signal a problem is occurring.

Using a single existing electrocardiogram (ECG) waveform, the early warning system aims to continuously detect the emergence of hemodynamic instability and forecast patient trajectory, giving doctors and nurses a heads up about impending trouble hours in advance of other methods.

Fifth Eye’s browser-based user interface provides the first score in five minutes with no baseline needed, minute-to-minute continuous patient assessment, advance warning and real-time treatment feedback, and easy to interpret historical trends without the need for electronic health record inputs.

How Analytic for Hemodynamic Instability (AHI) Works

The human body’s hemodynamic compensatory mechanisms, driven by the autonomic nervous system, protect against shifts in blood pressure to preserve critical organ function. However, such compensatory responses can mask underlying physiology and delay intervention, especially when relying on traditional vital signs. Once the vital signs and symptoms that show decompensation are evident, it may be too late to effectively intervene. Late detection of hemodynamic instability can lead to more invasive interventions, poorer outcomes, and even death.

AHI leverages the known relationships between the cardiac rhythm, heart rate variability and the autonomic nervous system. Using an innovative peak-detection and noise isolation approach, AHI examines precise beat-to-beat variations and morphological transitions within the ECG to quantify the physiologic and autonomic nervous system burden well before it is evident via traditional vitals. These nuanced cardiac variations associated with hemodynamic decompensation are typically obscure and cannot be visually observed by manual examination of streaming ECG, especially during the early period of its onset.

Plans for Funding

The funding will be used to secure FDA clearance of Fifth Eye’s first product, support clinical studies with multiple health systems, and enable the commercial launch of the company’s first product, the Analytic for Hemodynamic Instability. MCIRCC is collecting the data from 200 hospital beds at Michigan Medicine that was used to perform initial technology validation on AHI. FDA clearance is needed before the technology can be used for patients, which Baird hopes to receive clearance later this year.

Tom Shehab, MD, Managing Partner of Arboretum Ventures, Bill Schmidt, Managing Partner of Cultivation Capital and Mark Salamango, CTO of Fifth Eye will join Jen Baird, CEO of Fifth Eye on the Company’s Board of Directors.

“We are excited to have the strong support of such experienced healthcare investors as we bring our newly developed medical device software product through the FDA clearance process and into the hands of hospitals in the next two years. Saving lives is what motivates both our team and our clinical champions. This capital round gives us the fuel to accomplish those goals,” said Fifth Eye CEO, Jen Baird.

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

Tagged With: Blood Pressure, ecg, Electronic Health Record, FDA, FDA Clearance, Fifth Eye, Health Systems, Heart, MD, Medical Device, pneumonia, Predictive Analytics, Sepsis, Vital

Tap Native

Get in-depth healthcare technology analysis and commentary delivered straight to your email weekly

Reader Interactions

Primary Sidebar

Subscribe to HIT Consultant

Latest insightful articles delivered straight to your inbox weekly.

Submit a Tip or Pitch

Featured Insights

2025 EMR Software Pricing Guide

2025 EMR Software Pricing Guide

Featured Interview

Paradigm Shift in Diabetes Care with Studio Clinics: Q&A with Reach7 Founder Chun Yong

Most-Read

Medtronic to Separate Diabetes Business into New Standalone Company

Medtronic to Separate Diabetes Business into New Standalone Company

White House, IBM Partner to Fight COVID-19 Using Supercomputers

HHS Sets Pricing Targets for Trump’s EO on Most-Favored-Nation Drug Pricing

23andMe to Mine Genetic Data for Drug Discovery

Regeneron to Acquire Key 23andMe Assets for $256M, Pledges Continuity of Consumer Genome Services

CureIS Healthcare Sues Epic: Alleges Anti-Competitive Practices & Trade Secret Theft

The Evolving Role of Physician Advisors: Bridging the Gap Between Clinicians and Administrators

The Evolving Physician Advisor: From UM to Value-Based Care & AI

UnitedHealth Group Names Stephen Hemsley CEO as Andrew Witty Steps Down

UnitedHealth CEO Andrew Witty Steps Down, Stephen Hemsley Returns as CEO

Omada Health Files for IPO

Omada Health Files for IPO

Blue Cross Blue Shield of Massachusetts Launches "CloseKnit" Virtual-First Primary Care Option

Blue Cross Blue Shield of Massachusetts Launches “CloseKnit” Virtual-First Primary Care Option

Osteoboost Launches First FDA-Cleared Prescription Wearable Nationwide to Combat Low Bone Density

Osteoboost Launches First FDA-Cleared Prescription Wearable Nationwide to Combat Low Bone Density

2019 MedTech Breakthrough Award Category Winners Announced

MedTech Breakthrough Announces 2025 MedTech Breakthrough Award Winners

Secondary Sidebar

Footer

Company

  • About Us
  • Advertise with Us
  • Reprints and Permissions
  • Submit An Op-Ed
  • Contact
  • Subscribe

Editorial Coverage

  • Opinion
  • Health IT
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Population Health Management
    • Revenue Cycle Management
  • Digital Health
    • Artificial Intelligence
    • Blockchain Tech
    • Precision Medicine
    • Telehealth
    • Wearables
  • Startups
  • Value-Based Care
    • Accountable Care
    • Medicare Advantage

Connect

Subscribe to HIT Consultant Media

Latest insightful articles delivered straight to your inbox weekly

Copyright © 2025. HIT Consultant Media. All Rights Reserved. Privacy Policy |