• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Skip to secondary sidebar
  • Skip to footer

  • Opinion
  • Health IT
    • Behavioral Health
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Patient Engagement
    • Population Health Management
    • Revenue Cycle Management
    • Social Determinants of Health
  • Digital Health
    • AI
    • Blockchain
    • Precision Medicine
    • Telehealth
    • Wearables
  • Startups
  • M&A
  • Value-based Care
    • Accountable Care (ACOs)
    • Medicare Advantage
  • Life Sciences
  • Research

5 Ways SmartTrials is Advancing Precision Medicine Through Genomics

by Erica Garvin 06/04/2018 Leave a Comment

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

 5 Ways SmartTrials is Advancing Precision Medicine Through Genomics

Foundation Medicine’s Dr. Gaurav Singal shares how his company’s platform is changing the game in clinical trials and bolstering precision medicine through genomics.

The evolution may be slow going, but it looks like precision medicine is destined to disrupt many aspects of healthcare, and it’s already demonstrating that transformative power in clinical trials—where patient recruitment and retention have long plagued the process, according to Foundation Medicine’s Dr. Gaurav Singal.

“Current clinical trial design and patient identification and recruitment strategies are challenging, especially in a molecular-driven time,” said Singal, vice president of data strategy and product development at the Cambridge, MA-based genomic analysis and diagnostics provider. “Often, patients are narrowly defined and widely distributed geographically. As we worked with a multitude of pharma partners, we began to see this challenge reoccurring; partners were developing medicines for rarer targets and were having significant trouble getting those medicines to patients with those rare targets.”

Satisfying that need to match those more specialized patients and treatments more effectively was the inspiration behind FMI’s Smart Trials technology platform. The company is now using the platform in to rapidly match the right patients to precision trials through genomic testing and the identification of unique tumor biomarkers.

“We have a full suite of comprehensive genomic profiling assays to identify the molecular alterations in a patient’s cancer and match them with relevant, targeted therapies, immunotherapies, and clinical trials. Our molecular information platform aims to improve day-to-day care for patients by serving the needs of clinicians, academic researchers, and drug developers to help advance the science of molecular medicine in cancer,” said Singal.

5 Ways SmartTrials is Advancing Precision Medicine Through Genomics

There is no doubt there is reciprocity between the advancements of clinical trials and precision medicine. Precision-focused tools like SmartTrials are uncovering the connections between patients and personalized treatments—and the data from those trials will ultimately be used to further advanced those precision-based tools, care-access techniques, and treatments. It’s with that aim in mind, SmartTrials is already demonstrating its power in several ways within several clinical trials.

Here are five ways this innovative platform is advancing precision medicine research and development and transforming the clinical trial process along the way:

1. Boosting Enrollment: SmartTrials is helping to accelerate patient enrollment in TAPUR, a biomarker-driven clinical trial. Foundation Medicine is leveraging patients’ genomic profiling results to connect them to TAPUR trial sights automatically. Use of SmartTrials in TAPUR has already led to a significant increase in patient enrollment, reporting more than 60 patients within a few months of implementing the technology at one site.

2. Advancing Access and Eligibility: SmartTrials is also supporting enrollment for The National Cancer Institute’s (NCI) “MATCH” precision medicine trial. SmartTrials will automatically notify physicians when their patients’ genomic profiling results make them eligible for a treatment arm within the trial.

3. Improving Drug Development: Research results recently highlighted how SmartTrials helped match non-small cell lung cancer patients to a Phase II trial based on their biomarker. Researchers concluded that these “innovative partnerships, combined with computational matching infrastructure, could improve drug development and therapeutic access.”

4. Demonstrating the Benefit of Genomic Matching: Loxo’s Larotrectinib could be available to patients with the TRK biomarker as early as next year and Merck’s Keytruda was FDA approved recently for patients with the MSI biomarker. Both therapies are evidence that more patients could benefit from joining clinical trials based on their biomarker.

5. Saving Lives: FMI has witnessed firsthand the personal benefits of genomic matching. One example: a prostate cancer patient named David, who’s genomic testing results guided him to a clinical trial that wasn’t even studying prostate cancer at the time. However, because the therapy was targeted to his cancer’s specific makeup, David’s enrollment turned out to be a lifesaver. He is now in complete remission.

Perhaps the most compelling advancements are the ones that seem the most personal: “Stories like David’s support the benefits of precision medicine-based approaches for clinical research and treatment. As the field discovers therapeutic targets or biomarkers, more patients have the potential to receive lifesaving treatment,” Singal concluded.

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

Tagged With: Clinical Genomics, Clinical Trials, Foundation Medicine, genomics data, Precision Medicine, SmartTrials

Tap Native

Get in-depth healthcare technology analysis and commentary delivered straight to your email weekly

Reader Interactions

Primary Sidebar

Subscribe to HIT Consultant

Latest insightful articles delivered straight to your inbox weekly.

Submit a Tip or Pitch

Featured Insights

2025 EMR Software Pricing Guide

2025 EMR Software Pricing Guide

Featured Interview

Kinetik CEO Sufian Chowdhury on Fighting NEMT Fraud & Waste

Most-Read

2019 MedTech Breakthrough Award Category Winners Announced

MedTech Breakthrough Announces 2025 MedTech Breakthrough Award Winners

WeightWatchers Files for Bankruptcy to Eliminate $1.15B in Debt

WeightWatchers Files for Bankruptcy to Eliminate $1.15B in Debt

KLAS: Epic Dominates 2024 EHR Market Share Amid Focus on Vendor Partnership; Oracle Health Sees Losses Despite Tech Advances

KLAS: Epic Dominates 2024 EHR Market Share Amid Focus on Vendor Partnership; Oracle Health Sees Losses Despite Tech Advances

'Cranky Index' Reveals EHR Alert Frustration Peaks Midweek, Highest Among Admin Staff

‘Cranky Index’ Reveals EHR Alert Frustration Peaks Midweek, Highest Among Admin Staff

Madison Dearborn Partners to Acquire Significant Stake in NextGen Healthcare

Madison Dearborn Partners to Acquire Significant Stake in NextGen Healthcare

Wandercraft Begins Clinical Trials for Physical AI-Powered Personal Exoskeleton

Wandercraft Begins Clinical Trials for Physical AI-Powered Personal Exoskeleton

Chipiron Secures $17M to Transform MRI Access with Portable Scanner

Chipiron Secures $17M to Transform MRI Access with Portable Scanner

Abbott to Integrate FreeStyle Libre Glucose Data with Epic EHR

Abbott to Integrate FreeStyle Libre Glucose Data with Epic EHR

5 Ways New Trump Administration Tariffs Are Impacting U.S. Healthcare Now

5 Ways Trump Administration Tariffs Are Impacting U.S. Healthcare Now

iCAD, GE HealthCare Integrate to Advance Breast Cancer Detection with AI

RadNet to Acquire iCAD for $103M in All-Stock Transaction

Secondary Sidebar

Footer

Company

  • About Us
  • Advertise with Us
  • Reprints and Permissions
  • Submit An Op-Ed
  • Contact
  • Subscribe

Editorial Coverage

  • Opinion
  • Health IT
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Population Health Management
    • Revenue Cycle Management
  • Digital Health
    • Artificial Intelligence
    • Blockchain Tech
    • Precision Medicine
    • Telehealth
    • Wearables
  • Startups
  • Value-Based Care
    • Accountable Care
    • Medicare Advantage

Connect

Subscribe to HIT Consultant Media

Latest insightful articles delivered straight to your inbox weekly

Copyright © 2025. HIT Consultant Media. All Rights Reserved. Privacy Policy |