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HHS Launches ‘OneHHS’ AI Strategy to Integrate AI Across CDC, CMS, and FDA for Efficiency and Public Trust

by Fred Pennic 12/04/2025 Leave a Comment

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What You Should Know: 

– The U.S. Department of Health and Human Services (HHS) has released its comprehensive AI Strategy, fulfilling the Trump Administration’s commitment to utilize leading technologies across the federal workforce. 

– The “OneHHS” approach aims to integrate AI across all divisions—including the CDC, CMS, and FDA—to enhance internal operations, foster innovation, and ultimately improve patient outcomes. The strategy is built on five pillars, prioritizing governance, risk management, workforce development, and public health modernization.

HHS Unlocks AI Power with Unified Department-Wide Strategy

The integration of artificial intelligence into government operations is reaching a new milestone in the healthcare sector. The U.S. Department of Health and Human Services (HHS) today released its comprehensive AI Strategy, marking the next phase of a transformative initiative to integrate AI across internal operations, research, and public health.

This move delivers on the Trump Administration’s commitment to utilize leading technologies to enhance efficiency, foster American innovation, improve patient outcomes, and “Make America Healthy Again”.

“AI has the potential to revolutionize health care and human services, and HHS is leading that paradigm shift,” said Deputy Secretary of Health and Human Services Jim O’Neill.

The ‘OneHHS’ Approach: Unifying Federal Health Tech

A key feature of this strategy is the “OneHHS” approach, a first in the Department’s history. This approach invites all HHS divisions to collaborate in the development of one robust, Department-wide AI infrastructure.

This includes the most critical agencies that shape the healthcare landscape:

  • Centers for Disease Control and Prevention (CDC)
  • Centers for Medicare & Medicaid Services (CMS)
  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)

By centralizing infrastructure, the strategy aims to streamline workflows and enhance cybersecurity across the entire federal health apparatus.

The Five Pillars of the HHS AI Strategy

Led by Acting Chief Artificial Intelligence Officer Clark Minor, the strategy delivers on previous mandates, including the Trump Administration’s AI Action Plan. The strategy is founded on five core pillars, which will be continually revisited and updated to optimize AI’s impact:

  1. Ensure governance and risk management for public trust.
  2. Design infrastructure and platforms for user needs.
  3. Promote workforce development and burden reduction for efficiency.
  4. Foster health research and reproducibility through gold standard science.
  5. Enable care and public health delivery modernization for better outcomes.

“This Strategy is about harnessing AI to empower our workforce and drive innovation across the Department,” said Minor.

Paving the Way for Private Sector Collaboration

While this first step focuses primarily on improving internal operations, efficiency, and federal use as directed by the Office of Management and Budget (OMB), the ultimate goal is much broader.

The strategy is specifically designed to pave the way for engagement with private sector stakeholders to co-create solutions that maximize AI’s potential. This signals a major opportunity for health tech companies, as the framework will ultimately dictate how federal agencies will interface with private AI solutions.

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Tagged With: Artificial Intelligence

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