What You Should Know:
– The first large, real-world study of the effectiveness of mRNA COVID-19 vaccines during pregnancy found these vaccines, especially two initial doses followed by a booster, are effective in protecting against serious disease in expectant mothers whether the shots are administered before or during pregnancy
– Pregnant women were excluded from COVID-19 mRNA vaccine clinical trials, so this new study fills a significant knowledge gap, providing strong evidence that vaccinating women who are or might become pregnant protects against hospitalization for the disease during pregnancy.
Data-Driven Analysis of Vaccinating Pregnant Women For COVID-19
Founded in 1969 in Indianapolis, the Regenstrief Institute is a local, national and global leader dedicated to a world where better information empowers people to end disease and realize true health. A key research partner to Indiana University, Regenstrief and its research scientists are responsible for a growing number of major healthcare innovations and studies. Examples range from the development of global health information technology standards that enable the use and interoperability of electronic health records to improving patient-physician communications, to creating models of care that inform practice and improve the lives of patients around the globe.
The first large, real-world study of the effectiveness of mRNA COVID-19 vaccines during pregnancy found these vaccines, especially two initial doses followed by a booster, are effective in protecting against serious disease in expectant mothers whether the shots are administered before or during pregnancy. “That two doses plus a booster are known to be safe and demonstrate protection against severe disease in pregnant women is reassuring, given growing evidence of increased risk of poor maternal outcomes associated with COVID-19 infection during pregnancy,” said study co-author Brian Dixon, PhD, MPA, director of public health informatics for Regenstrief Institute and Indiana University Richard M. Fairbanks School of Public Health. “This strongly suggests that, along with other preventive measures that expectant mothers or women who are considering getting pregnant can take to promote a healthy pregnancy, getting vaccinated and boosted against COVID should be high on the list.” Dr. Dixon also is the interim director of the Regenstrief Center for Biomedical Informatics.
The researchers found that mRNA COVID-19 vaccination protects pregnant women against emergency department (E.D.) or urgent care center visits and protects even more strongly against hospitalizations for COVID-19, three venues for receipt of medical attention for the disease. As with other evaluations of mRNA COVID-19 vaccines in adults, a lower effectiveness in protecting against E.D. and urgent care visits than for hospitalizations was seen in pregnant women, most significantly in the Omicron period among those receiving only two vaccine doses.
Also, similar to findings among non-pregnant adults, two-dose protection waned over time (after four months) and vaccine effectiveness was highest among pregnant women with three doses (initial two vaccinations plus a booster shot).
Data on a total of 3,445 E.D. or urgent care visits and 781 hospitalizations among pregnant women with COVID-19 confirmed by molecular testing was extracted from electronic medical records from 306 hospitals and 164 E.D. and urgent care facilities in eight health systems across 10 U.S. states. This information was analyzed by the VISION network, which includes Baylor Scott & White Health (Texas), Columbia University Irving Medical Center (New York), HealthPartners (Minnesota and Wisconsin), Intermountain Healthcare (Utah), Kaiser Permanente Northern California (California), Kaiser Permanente Northwest (Oregon and Washington), Regenstrief Institute (Indiana), and University of Colorado (Colorado).
“This study indicates that pregnancy doesn’t diminish mRNA vaccine performance in protecting against severe COVID-19 despite immune differences between pregnant and non-pregnant women,” said study co-author Shaun Grannis, M.D., M.S., vice president for data and analytics at Regenstrief Institute, Regenstrief Professor of Medical Informatics and professor of family medicine at Indiana University School of Medicine. “Vaccine utilization among expectant mothers remains low compared to similarly aged non-pregnant individuals for both the first two vaccines and a booster dose. Hopefully, this study will provide pregnant women with the evidence they need to get vaccinated and boosted.” Current guidance from the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists recommends that all pregnant women receive two vaccine doses and a booster dose, with a preference for mRNA vaccines.
Furthermore, data suggests that pregnant women who have been vaccinated should still follow all safety precautions, including physical distancing, wearing face coverings, and frequent handwashing.
Vaccinating against COVID-19 is part of a comprehensive approach to mitigating the spread of infection in the community. The findings from this study must be taken together with other measures to protect pregnant women and their babies against COVID-19. If you suspect yourself to be pregnant, use a pregnancy test calculator to know when the best time for a pregnancy test is. The institute also hopes that the data will encourage pregnant women to get vaccinated as soon as they are able. This way, they can help protect themselves, their babies, and the community.
On the other hand, for women who are not yet sure if they are pregnant or want to find out how far along they are in their pregnancy, there’s a reliable due date calculator available online to help them determine their due date and other vital information. This tool can help women determine how far along they are in their pregnancies and whether or not it’s safe for them to get vaccinated against COVID-19.
Ultimately, this study gives expectant mothers peace of mind that getting vaccinated is a safe and effective way to protect themselves from serious diseases during pregnancy. With further studies, researchers hope to understand more about how mRNA COVID-19 vaccine safety and effectiveness may vary by trimester of pregnancy and other factors. Until then, pregnant women can protect themselves and their babies using a combination of preventive measures.
“Estimation of COVID-19 mRNA Vaccine Effectiveness Against Medically Attended COVID-19 in Pregnancy During Periods of Delta and Omicron Variant Predominance in the United States” is published in JAMA Network Open.