• Skip to main content
  • Skip to secondary menu
  • Skip to primary sidebar
  • Skip to secondary sidebar
  • Skip to footer

  • Opinion
  • Health IT
    • Behavioral Health
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Patient Engagement
    • Population Health Management
    • Revenue Cycle Management
    • Social Determinants of Health
  • Digital Health
    • AI
    • Blockchain
    • Precision Medicine
    • Telehealth
    • Wearables
  • Life Sciences
  • Investments
  • M&A
  • Value-based Care
    • Accountable Care (ACOs)
    • Medicare Advantage

Mission Bio Unveils Industry-First Single-Cell Genotype and Targeted Gene Expression Solution

by Syed Hamza Sohail 06/05/2025 Leave a Comment

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

What You Should Know:

– Mission Bio, a leader in single-cell multiomics solutions for precision medicine, today announced the launch of its Single-Cell Genotype and Targeted Gene Expression assay, expanding the capabilities of its Tapestri Platform to become the only commercial solution that delivers simultaneous genotype and targeted gene expression profiling from over 10,000 single cells.

– The assay, which can be leveraged for Phase 2 or 3 trials to home in on patients most likely to benefit from a cancer therapy, will be unveiled at the European Hematology Association (EHA) meeting in Milan, Italy.

Mission Bio Launches Multi-Modal Single-Cell Assay to Advance Precision Oncology

Mission Bio has introduced a new Single-Cell Genotype and Targeted Gene Expression assay as part of its Pharma Assay Development (PAD) services, offering end-to-end support from custom assay design to data interpretation and technology transfer. This multi-modal assay provides pharmaceutical partners with a high-resolution understanding of cancer cell behavior, with three primary applications: uncovering mechanisms of therapeutic resistance, informing next-generation T-cell therapy design, and improving patient selection in clinical trials.

The assay is specifically designed to overcome challenges in characterizing tumor heterogeneity and resistance pathways—persistent bottlenecks in oncology drug development. Existing methods often fall short of providing integrated insights across genomic and transcriptomic layers. By capturing both genomic mutations and targeted gene expression changes within the same cell, the enhanced Tapestri Platform delivers a unified, high-resolution view of treatment response and disease progression, helping de-risk late-stage development.

Mission Bio CEO Brian Kim noted that most clinical failures in hematologic oncology occur during Phase II or III trials due to poor patient response and a lack of robust predictive biomarkers. He emphasized that this new capability helps identify which patients are most likely to respond to specific therapies, aligning with Mission Bio’s broader goal of enabling precision medicine through single-cell analytics.

The assay also includes sample multiplexing, reducing the cost of single-cell analysis by approximately 60% compared to using separate technologies for similar insights. Early adopters of the Tapestri Platform have already integrated targeted gene expression with single-cell genotyping and multi-omics workflows, highlighting its utility in applications such as tracking clonal evolution and resistant subclones in AML under therapeutic pressure.

Future development by the PAD team will include adding immunophenotyping to the assay, enabling true multi-omic profiling at the single-cell level for deeper insights into tumor-immune interactions and therapeutic impact.

  • LinkedIn
  • Twitter
  • Facebook
  • Email
  • Print

Tap Native

Get in-depth healthcare technology analysis and commentary delivered straight to your email weekly

Reader Interactions

Primary Sidebar

Subscribe to HIT Consultant

Latest insightful articles delivered straight to your inbox weekly.

Submit a Tip or Pitch

Featured Interview

Reach7 Diabetes Studios Founder Chun Yong on Reimagining Chronic Care with a Concierge Medical Model

Most-Read

Advancing Diabetes Care: Combating Burnout and Harnessing Technology

Advancing Diabetes Care: Combating Burnout and Harnessing Technology

White House Event Unveils CMS Health Tech Ecosystem Initiative

White House Event Unveils CMS Health Tech Ecosystem Initiative

Meaningful Use Penalties_Meaningful Use_Partial Code Free_Senators Urge CMS to Establish Clear Metrics for ICD-10 Testing

CMS Finalizes TEAM Model: A New Era of Value-Based Surgical Care

HHS Finalizes HTI-4 Rule: Prior Authorization & E-Prescribing Interoperability

HHS Finalizes HTI-4 Rule: Prior Authorization & E-Prescribing Interoperability

Digital Health Faces Q2'25 Pullback: Funding Falls to 5-Year Low, But AI Dominates and $1B+ IPOs Emerge

Healthcare Investment Shifts in 1H 2025: AI Remains a Bright Spot Amidst Fundraising Decline

Digital Health Faces Q2'25 Pullback: Funding Falls to 5-Year Low

Digital Health Faces Q2’25 Pullback: Funding Falls to 5-Year Low

Beyond the Hype: Building AI Systems in Healthcare Where Hallucinations Are Not an Option

Beyond the Hype: Building AI Systems in Healthcare Where Hallucinations Are Not an Option

Health IT Sector Navigates Policy Turbulence with Resilient M&A

Health IT’s New Chapter: IPOs Return, Resilient M&A, Valuations Rise in 1H 2025

PwC Report: US Medical Cost Trend to Remain Elevated at 8.5% in 2026

PwC Report: US Medical Cost Trend to Remain Elevated at 8.5% in 2026

Philips Launches ECG AI Marketplace, Partnering with Anumana to Enhance Cardiac Care with AI-Powered Diagnostics

Philips Launches ECG AI Marketplace, Partnering with Anumana to Enhance Cardiac Care with AI-Powered Diagnostics

Secondary Sidebar

Footer

Company

  • About Us
  • Advertise with Us
  • Reprints and Permissions
  • Submit An Op-Ed
  • Contact
  • Subscribe

Editorial Coverage

  • Opinion
  • Health IT
    • Care Coordination
    • EMR/EHR
    • Interoperability
    • Population Health Management
    • Revenue Cycle Management
  • Digital Health
    • Artificial Intelligence
    • Blockchain Tech
    • Precision Medicine
    • Telehealth
    • Wearables
  • Startups
  • Value-Based Care
    • Accountable Care
    • Medicare Advantage

Connect

Subscribe to HIT Consultant Media

Latest insightful articles delivered straight to your inbox weekly

Copyright © 2025. HIT Consultant Media. All Rights Reserved. Privacy Policy |