What You Should Know:
- AION Labs, the first-of-its-kind venture studio spearheading the adoption of AI technologies and computational science to solve therapeutic challenges, announced today the formation of TenAces Biosciences.
- TenAces is a startup developing a novel approach to discover new molecular glue therapies, leveraging machine learning to enhance development of treatments for a range of conditions.
Revolutionizing Molecular Glue Discovery with AI-Driven Targeted Protein Degradation
TenAces, originating from AION Labs’ fifth startup challenge, is developing an AI platform focused on identifying natural protein interactions for targeted protein degradation. This innovative solution aims to streamline the discovery of molecular glue therapies, departing from the traditional serendipitous discovery method. TenAces employs machine learning to analyze interactions, protein pairs, and multi-dimensional features, predicting new molecular glues.
What sets TenAces apart is its unique integration of biology into machine learning algorithms, utilizing multiple feedback loops with wet lab validations to enhance predictive capabilities. The founding team includes Chief AI Officer Dr. Tomer Sidi, an expert in deep learning and bioinformatics, and Bioinformatics Lead Dr. Chen Lior, with a strong background in bioinformatics and experimental biology, both contributing to the groundbreaking approach.
“We are developing a novel solution for targeted protein degradation by enabling the identification of optimal E3 degraders and designing molecular glues for removal of disease-causing proteins. With some 85% of target proteins currently undruggable, we can potentially address a wide range of diseases,” said Arnout Schepers, PhD, Founder and CEO of TenAces. “AION Labs has proven invaluable in facilitating the establishment of TenAces. The support of our pharma partners has been integral in shaping the company, providing the essential resources and guidance necessary to develop and eventually commercialize solutions that can facilitate more effective treatment.”
